(S)-1-Boc-3-hydroxypiperidine
Sharaxaad Gaaban:
CAS: 143900-44-1
MF: C10H19NO3
MW: 201.26
Qaybaha Alaabta
ChiralReagents, Piperidines; Heterocycles; Dhexdhexaadiyaha & Kiimikada Fiican; Daawooyinka; Dawooyinka
La mid ah
(S)-1-Boc-3-Hydroxypiperidine
(S)-1-N-BOC-3-HYDROXY-PIPERIDINE
(S)-3-HYDROXY-PIPERIDINE-1-KARBOXYLIC AACID TERT-BUTYL ESTER
(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDIN
(S)-1-BOC-3-PIPERIDINOL
(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCLORIDE
(S)-N-BOC-3-HYDROXY PIPERIDINE
(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-KARBOXYLATE
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
S-1-Boc-3-hydroxypiperidine
(3S)-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
(S)-3,5-DifluoroMandelic acid
(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate
(S)-tert-Butyl-3-hydroxypiperidine-1-carboxylate tert-butyl
(3S)-3-hydroxy piperidine-1-carboxylate tert-butyl
(S)-3-hydroxypiperidine-1-carboxylate
(3S)-3-Hydroxypiperidine, N-BOC waa la ilaaliyay
(S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine
Guryaha Kiimikada
Meesha dhalaalka: 34-40 °C
Barta karkarinta: 292.3 ± 33.0 °C (La saadaaliyay)
Cufnaanta: 1.107± 0.06 g/cm3 (La saadaaliyay)
Fp: 110 °C
heerkulka kaydinta: Ku hay meel mugdi ah, ku xidhan meel engegan, heerkulka qolka
milmay: Ku milmay methanol.
Pka: 14.74±0.20 (La saadaaliyay)
Foomka: budada ama budada crystalline
Midabka: Caddaan ilaa tan
dhaqdhaqaaqa indhaha: [α]22/D +10.0°, c = 1 ee chloroform
InChIKey: UIJXHKXIOCDSEB-QMMMGPOBSA-N
Aqoonsiga halista
1 Kala saarista walaxda ama isku dhafka
Xanaaq maqaarka, Qaybta 2
Xannuun indhaha, Qaybta 2
Sunta xubnaha bartilmaameedka ah ee gaarka ah - soo-gaadhis keli ah, Qaybta 3
2 calaamada GHS, oo ay ku jiraan bayaannada taxaddarka
| Sawir-gacmeed |  |
| Erayga calaamada | Digniin |
| Bayaanka(yada) Hazard | H315 waxay sababtaa cuncun maqaarka H319 waxay sababtaa cuncun isha oo daran H335 waxay keeni kartaa cuncun xagga neefsashada ah |
| Odhaah(yada) taxaddarka | |
| Ka hortagga | P264 Ku dhaq ... si fiican u dhaq ka dib. P280 Xidho galoofyada ilaalinta/dharka ilaalinta/ilaalinta indhaha/ ilaalinta wajiga/ ilaalinta maqalka/... P261 Iska ilaali siigada neefsashada/qiiqa/gaaska/ ceeryaamo/ uumiga/ buufiska. P271 Ku isticmaal bannaanka ama meel hawo fiican leh oo keliya. |
| Jawaabta | P302+P352 HADDII MAQAARKA UU YAHAY: Ku dhaq biyo badan/... P321 daawaynta gaarka ah (fiiri ... sumaddan). P332+P317 Haddii maqaarka xanaaqa dhaco: hel gargaar caafimaad. P362+P364 Iska siib dharka wasakhaysan oo dhaq ka hor inta aan dib loo isticmaalin. P305+P351+P338 HADDII INDHAHA LAGU JIRO: Si taxadir leh ugu raaci biyo dhowr daqiiqo.Ka saar muraayadaha indhaha, haddii ay jiraan oo ay fududahay in la sameeyo.Sii wad biyo raacida P304+P340 HADDII LA ISKU NAXO: Ka saar qofka hawo cusub oo ku raaxayso neefsashada. P319 Hel gargaar caafimaad haddii aad dareento xanuun. |
| Kaydinta | P403+P233 Ku kaydi meel hawo fiican leh.Weelka si adag u xidh. Bakhaarka P405 waa la xidhay. |
| Tuur | P501 Ku tuur waxa ku jira/koonteenar ku rid daawaynta ku habboon iyo tas-hiilaadka qashin-qubka si waafaqsan shuruucda iyo qawaaniinta khuseeya, iyo sifooyinka alaabta wakhtiga la tuurayo. |
3 Khataraha kale oo aan keenin kala saarid
xog lama hayo
Tilmaamaha Alaabta
| Muuqashada/midabka | Cadaan ilaa cad-cad adag Waxay noqon kartaa agglomerate ka dib kaydinta waqtiyo dheer |
| Aqoonsiga (IR) | u dhiganta |
| Qiimaynta (HPLC w/w) | 97.0% -103.0% |
| Nadiifinta kiimikaad (aagga GC) | ﹥﹦ 99.0% |
| Nadiifinta wasakhda (GC w/w) | 3-Hydroxypiperidine﹤﹦ 0.1% |
| 3-Hydroxypyridine﹤﹦ 0.20% | Lama ogaan |
| 1-Boc-3-piperidone﹤﹦ 0.10% | Lama ogaan |
| 1-Boc-4-hydroxypiperidine﹤﹦ 0.10% | Lama ogaan |
| 1.96RRT﹤﹦ 0.2% | Lama ogaan |
| Wax kasta oo wasakh ah oo aan la cayimin﹤﹦ 0.08% | 0.01% |
| Nadiifnimada Chiral (HPLC aagga) | ﹥﹦ 99.5% |
| Methanol (GC) | ﹤﹦ 50pm |
| Ethanol (GC) | ﹤﹦ 50pm |
| DCM(GC) | ﹤﹦ 500pm |
| Biyaha (KF vol w/w) | ﹤﹦ 0.5% |
Faa'iidooyinkayaga
1: Warshadeenu waxay xaqiiqsatay wax soo saarka ganacsi ee weyn tan iyo sanadkii 2012, Qadarka iibka sanadlaha ah wuxuu gaaray in ka badan 20tons.
2 Waxay ahayd alaab-qeybiye u qalma shirkadda dawooyinka patent-ka ee Ibrutinib.
3 Tayada alaabadu waa heer sare: Qiimayn: 97.0% -103.0%
Nadiifinta kiimikada (aagga GC): ﹦ 99.0%
Wasakh kasta oo aan la cayimin ﹤ ﹦ 0.08%
Nadiifnimada Chiral (aagga HPLC): ﹥ ﹦ 99.5%
4 Waxa lagu sameeyaa habka Xallinta Kiimikada.
5 Dhammaan hababka tijaabada waa la ansixiyay.
6 Hal aqoon isweydaarsi u go'ay samayntiisa.
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